Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein

mRNA expression of the DLC1 tumor suppressor gene is downregulated in many lung cancers and their derived cell lines, with DLC1 protein levels being low or absent. Although the role of increased EZH2 methyltransferase in cancer is usually attributed to its histone methylation, we unexpectedly observ...

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Detalles Bibliográficos
Autores principales: Tripathi, Brajendra K., Anderman, Meghan F., Bhargava, Disha, Boccuzzi, Luciarita, Qian, Xiaolan, Wang, Dunrui, Durkin, Marian E., Papageorge, Alex G., de Miguel, Fernando J., Politi, Katerina, Walters, Kylie J., Doroshow, James H., Lowy, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642553/
https://www.ncbi.nlm.nih.gov/pubmed/34862367
http://dx.doi.org/10.1038/s41467-021-26993-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642553/
https://www.ncbi.nlm.nih.gov/pubmed/34862367
http://dx.doi.org/10.1038/s41467-021-26993-3

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