Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex

Antibody drugs exert therapeutic effects via a range of mechanisms, including competitive inhibition, allosteric modulation, and immune effector mechanisms. Facilitated dissociation is an additional mechanism where antibody-mediated “disruption” of stable high-affinity macromolecular complexes can p...

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Detalles Bibliográficos
Autores principales: Pennington, Luke F., Gasser, Pascal, Kleinboelting, Silke, Zhang, Chensong, Skiniotis, Georgios, Eggel, Alexander, Jardetzky, Theodore S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642555/
https://www.ncbi.nlm.nih.gov/pubmed/34862384
http://dx.doi.org/10.1038/s41467-021-27397-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642555/
https://www.ncbi.nlm.nih.gov/pubmed/34862384
http://dx.doi.org/10.1038/s41467-021-27397-z

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