Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy

Protein neddylation is catalyzed by a three-enzyme cascade, namely an E1 NEDD8-activating enzyme (NAE), one of two E2 NEDD8 conjugation enzymes and one of several E3 NEDD8 ligases. The physiological substrates of neddylation are the family members of cullin, the scaffold component of cullin RING lig...

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Detalles Bibliográficos
Autores principales: Li, Yanan, Wang, Chaorong, Xu, Tiantian, Pan, Peichen, Yu, Qing, Xu, Lei, Xiong, Xiufang, Hou, Tingjun, Cui, Sunliang, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642603/
https://www.ncbi.nlm.nih.gov/pubmed/34900537
http://dx.doi.org/10.1016/j.apsb.2021.07.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642603/
https://www.ncbi.nlm.nih.gov/pubmed/34900537
http://dx.doi.org/10.1016/j.apsb.2021.07.012

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