Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

Glioblastoma multiforme (GBM) in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it. Studies of sinomenine, an alkaloid from the Chinese medicinal plant, Sinomenium acutum, showed that it had inhibitory effects on several kinds of cance...

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Detalles Bibliográficos
Autores principales: Zheng, Xiangjin, Li, Wan, Xu, Huanli, Liu, Jinyi, Ren, Liwen, Yang, Yihui, Li, Sha, Wang, Jinhua, Ji, Tengfei, Du, Guanhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642618/
https://www.ncbi.nlm.nih.gov/pubmed/34900530
http://dx.doi.org/10.1016/j.apsb.2021.05.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642618/
https://www.ncbi.nlm.nih.gov/pubmed/34900530
http://dx.doi.org/10.1016/j.apsb.2021.05.027

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