N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties

Proline dehydrogenase (PRODH) is a mitochondrial inner membrane flavoprotein critical for cancer cell survival under stress conditions and newly recognized as a potential target for cancer drug development. Reversible (competitive) and irreversible (suicide) inhibitors of PRODH have been shown in vi...

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Detalles Bibliográficos
Autores principales: Scott, Gary K., Mahoney, Sophia, Scott, Madeleine, Loureiro, Ashley, Lopez-Ramirez, Alejandro, Tanner, John J., Ellerby, Lisa M., Benz, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643368/
https://www.ncbi.nlm.nih.gov/pubmed/34089390
http://dx.doi.org/10.1007/s00726-021-03012-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643368/
https://www.ncbi.nlm.nih.gov/pubmed/34089390
http://dx.doi.org/10.1007/s00726-021-03012-9

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