Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis

DNA damage and apoptosis lead to the release of free nucleosomes—the basic structural repeating units of chromatin—into the blood circulation system. We recently reported that free nucleosomes that enter the cytoplasm of mammalian cells trigger immune responses by activating cGMP-AMP synthase (cGAS)...

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Detalles Bibliográficos
Autores principales: Wang, Huawei, Shan, Xiajing, Ren, Mengtian, Shang, Mengdi, Zhou, Chuanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643636/
https://www.ncbi.nlm.nih.gov/pubmed/34865123
http://dx.doi.org/10.1093/nar/gkab1121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643636/
https://www.ncbi.nlm.nih.gov/pubmed/34865123
http://dx.doi.org/10.1093/nar/gkab1121

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