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Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis
DNA damage and apoptosis lead to the release of free nucleosomes—the basic structural repeating units of chromatin—into the blood circulation system. We recently reported that free nucleosomes that enter the cytoplasm of mammalian cells trigger immune responses by activating cGMP-AMP synthase (cGAS)...
Autores principales: | Wang, Huawei, Shan, Xiajing, Ren, Mengtian, Shang, Mengdi, Zhou, Chuanzheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643636/ https://www.ncbi.nlm.nih.gov/pubmed/34865123 http://dx.doi.org/10.1093/nar/gkab1121 |
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