Engineering large-scale chromosomal deletions by CRISPR-Cas9

Large-scale chromosomal deletions are a prevalent and defining feature of cancer. A high degree of tumor-type and subtype specific recurrencies suggest a selective oncogenic advantage. However, due to their large size it has been difficult to pinpoint the oncogenic drivers that confer this advantage...

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Detalles Bibliográficos
Autores principales: Eleveld, Thomas F, Bakali, Chaimaa, Eijk, Paul P, Stathi, Phylicia, Vriend, Lianne E, Poddighe, Pino J, Ylstra, Bauke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643637/
https://www.ncbi.nlm.nih.gov/pubmed/34230973
http://dx.doi.org/10.1093/nar/gkab557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643637/
https://www.ncbi.nlm.nih.gov/pubmed/34230973
http://dx.doi.org/10.1093/nar/gkab557

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