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Engineering large-scale chromosomal deletions by CRISPR-Cas9

Large-scale chromosomal deletions are a prevalent and defining feature of cancer. A high degree of tumor-type and subtype specific recurrencies suggest a selective oncogenic advantage. However, due to their large size it has been difficult to pinpoint the oncogenic drivers that confer this advantage...

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Detalles Bibliográficos
Autores principales:	Eleveld, Thomas F, Bakali, Chaimaa, Eijk, Paul P, Stathi, Phylicia, Vriend, Lianne E, Poddighe, Pino J, Ylstra, Bauke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	NAR Breakthrough Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643637/ https://www.ncbi.nlm.nih.gov/pubmed/34230973 http://dx.doi.org/10.1093/nar/gkab557

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