Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA

Watson–Crick base pairs (bps) are the fundamental unit of genetic information and the building blocks of the DNA double helix. However, A-T and G-C can also form alternative ‘Hoogsteen’ bps, expanding the functional complexity of DNA. We developed ‘Hoog-finder’, which uses structural fingerprints to...

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Detalles Bibliográficos
Autores principales: Shi, Honglue, Kimsey, Isaac J, Gu, Stephanie, Liu, Hsuan-Fu, Pham, Uyen, Schumacher, Maria A, Al-Hashimi, Hashim M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643651/
https://www.ncbi.nlm.nih.gov/pubmed/34792150
http://dx.doi.org/10.1093/nar/gkab936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643651/
https://www.ncbi.nlm.nih.gov/pubmed/34792150
http://dx.doi.org/10.1093/nar/gkab936

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