TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress

Telomeres are intrinsically difficult-to-replicate region of eukaryotic chromosomes. Telomeric repeat binding factor 2 (TRF2) binds to origin recognition complex (ORC) to facilitate the loading of ORC and the replicative helicase MCM complex onto DNA at telomeres. However, the biological significanc...

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Detalles Bibliográficos
Autores principales: Higa, Mitsunori, Matsuda, Yukihiro, Fujii, Jumpei, Sugimoto, Nozomi, Yoshida, Kazumasa, Fujita, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643664/
https://www.ncbi.nlm.nih.gov/pubmed/34761263
http://dx.doi.org/10.1093/nar/gkab1004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643664/
https://www.ncbi.nlm.nih.gov/pubmed/34761263
http://dx.doi.org/10.1093/nar/gkab1004

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