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TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress
Telomeres are intrinsically difficult-to-replicate region of eukaryotic chromosomes. Telomeric repeat binding factor 2 (TRF2) binds to origin recognition complex (ORC) to facilitate the loading of ORC and the replicative helicase MCM complex onto DNA at telomeres. However, the biological significanc...
Autores principales: | Higa, Mitsunori, Matsuda, Yukihiro, Fujii, Jumpei, Sugimoto, Nozomi, Yoshida, Kazumasa, Fujita, Masatoshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643664/ https://www.ncbi.nlm.nih.gov/pubmed/34761263 http://dx.doi.org/10.1093/nar/gkab1004 |
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