Genome-wide analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine at single-nucleotide resolution unveils reduced occurrence of oxidative damage at G-quadruplex sites

8-Oxo-7,8-dihydro-2′-deoxyguanosine (OG), one of the most common oxidative DNA damages, causes genome instability and is associated with cancer, neurological diseases and aging. In addition, OG and its repair intermediates can regulate gene transcription, and thus play a role in sensing cellular oxi...

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Detalles Bibliográficos
Autores principales: An, Jiao, Yin, Mengdie, Yin, Jiayong, Wu, Sizhong, Selby, Christopher P, Yang, Yanyan, Sancar, Aziz, Xu, Guo-Liang, Qian, Maoxiang, Hu, Jinchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643665/
https://www.ncbi.nlm.nih.gov/pubmed/34788860
http://dx.doi.org/10.1093/nar/gkab1022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643665/
https://www.ncbi.nlm.nih.gov/pubmed/34788860
http://dx.doi.org/10.1093/nar/gkab1022

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