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Genome-wide analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine at single-nucleotide resolution unveils reduced occurrence of oxidative damage at G-quadruplex sites
8-Oxo-7,8-dihydro-2′-deoxyguanosine (OG), one of the most common oxidative DNA damages, causes genome instability and is associated with cancer, neurological diseases and aging. In addition, OG and its repair intermediates can regulate gene transcription, and thus play a role in sensing cellular oxi...
Autores principales: | An, Jiao, Yin, Mengdie, Yin, Jiayong, Wu, Sizhong, Selby, Christopher P, Yang, Yanyan, Sancar, Aziz, Xu, Guo-Liang, Qian, Maoxiang, Hu, Jinchuan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643665/ https://www.ncbi.nlm.nih.gov/pubmed/34788860 http://dx.doi.org/10.1093/nar/gkab1022 |
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