TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhang

Human telomeres are protected by shelterin proteins, but how telomeres maintain a dynamic structure remains elusive. Here, we report an unexpected activity of POT1 in imparting conformational dynamics of the telomere overhang, even at a monomer level. Strikingly, such POT1-induced overhang dynamics...

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Detalles Bibliográficos
Autores principales: Paul, Tapas, Liou, Wilson, Cai, Xinyi, Opresko, Patricia L, Myong, Sua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643667/
https://www.ncbi.nlm.nih.gov/pubmed/34850123
http://dx.doi.org/10.1093/nar/gkab1123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643667/
https://www.ncbi.nlm.nih.gov/pubmed/34850123
http://dx.doi.org/10.1093/nar/gkab1123

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