Cargando…

Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs

Circular RNAs (circRNAs) are noncoding RNAs that exist in all eukaryotes investigated and are derived from back-splicing of certain pre-mRNA exons. Here, we report the application of artificial circRNAs designed to act as antisense-RNAs. We systematically tested a series of antisense-circRNAs target...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pfafenrot, Christina, Schneider, Tim, Müller, Christin, Hung, Lee-Hsueh, Schreiner, Silke, Ziebuhr, John, Bindereif, Albrecht
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643703/ https://www.ncbi.nlm.nih.gov/pubmed/34850109 http://dx.doi.org/10.1093/nar/gkab1096

Ejemplares similares

Design and application of circular RNAs with protein-sponge function
por: Schreiner, Silke, et al.
Publicado: (2020)

Small circRNAs with self-cleaving ribozymes are highly expressed in diverse metazoan transcriptomes
por: Cervera, Amelia, et al.
Publicado: (2020)

Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response
por: Luo, Shiqi, et al.
Publicado: (2018)

iRAPs curb antisense transcription in E. coli
por: Magán, Andrés, et al.
Publicado: (2019)

Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction
por: Wang, Lingyan, et al.
Publicado: (2020)

Global RNA profiles show target selectivity and physiological effects of peptide-delivered antisense antibiotics
por: Popella, Linda, et al.
Publicado: (2021)

Biophysical characterisation of human LincRNA-p21 sense and antisense Alu inverted repeats
por: D’Souza, Michael H, et al.
Publicado: (2022)

A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression
por: Goyal, Ashish, et al.
Publicado: (2017)

Comprehensive analysis of PNA-based antisense antibiotics targeting various essential genes in uropathogenic Escherichia coli
por: Popella, Linda, et al.
Publicado: (2022)

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells
por: Michaels, Wren E, et al.
Publicado: (2020)

Another layer of complexity in Staphylococcus aureus methionine biosynthesis control: unusual RNase III-driven T-box riboswitch cleavage determines met operon mRNA stability and decay
por: Wencker, Freya D R, et al.
Publicado: (2021)

HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing
por: Preußner, Marco, et al.
Publicado: (2012)

A guard protein mediated quality control mechanism monitors 5’-capping of pre-mRNAs
por: Klama, Sandra, et al.
Publicado: (2022)

Transcription attenuation-derived small RNA rnTrpL regulates tryptophan biosynthesis gene expression in trans
por: Melior, Hendrik, et al.
Publicado: (2019)

Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs
por: Thivierge, Caroline, et al.
Publicado: (2018)

Telomerase RNAs in land plants
por: Fajkus, Petr, et al.
Publicado: (2019)

TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes
por: Lee, Eliza S, et al.
Publicado: (2020)

Identification of clustered organellar short (cos) RNAs and of a conserved family of organellar RNA-binding proteins, the heptatricopeptide repeat proteins, in the malaria parasite
por: Hillebrand, Arne, et al.
Publicado: (2018)

Polycytidylation of mitochondrial mRNAs in Chlamydomonas reinhardtii
por: Salinas-Giegé, Thalia, et al.
Publicado: (2017)

Splicing of long non-coding RNAs primarily depends on polypyrimidine tract and 5′ splice-site sequences due to weak interactions with SR proteins
por: Krchňáková, Zuzana, et al.
Publicado: (2019)

KREH1 RNA helicase activity promotes utilization of initiator gRNAs across multiple mRNAs in trypanosome RNA editing
por: Dubey, Ashutosh P, et al.
Publicado: (2023)

Two-step mechanism for selective incorporation of lncRNA into a chromatin modifier
por: Müller, Marisa, et al.
Publicado: (2020)

Allosteric regulation of noncoding RNA function by microRNAs
por: Gorbea, Carlos, et al.
Publicado: (2022)

Reprograming of sRNA target specificity by the leader peptide peTrpL in response to antibiotic exposure
por: Melior, Hendrik, et al.
Publicado: (2021)

MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs
por: Sun, Qinyu, et al.
Publicado: (2018)

Intrinsic and regulated properties of minimally edited trypanosome mRNAs
por: Tylec, Brianna L, et al.
Publicado: (2019)

Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome
por: Tosar, Juan Pablo, et al.
Publicado: (2020)

Cis regulation within a cluster of viral microRNAs
por: Vilimova, Monika, et al.
Publicado: (2021)

Evolution of plant telomerase RNAs: farther to the past, deeper to the roots
por: Fajkus, Petr, et al.
Publicado: (2021)

On the rules of engagement for microRNAs targeting protein coding regions
por: Sapkota, Sunil, et al.
Publicado: (2023)

Differences in silencing of mismatched targets by sliced versus diced siRNAs
por: Sun, Guihua, et al.
Publicado: (2018)

Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells
por: Toompuu, Marina, et al.
Publicado: (2018)

Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins
por: Bohn, Jennifer A, et al.
Publicado: (2018)

Small nucleolar RNAs controlling rRNA processing in Trypanosoma brucei
por: Chikne, Vaibhav, et al.
Publicado: (2019)

Small RNA sequences derived from pre-microRNAs in the supraspliceosome
por: Mahlab-Aviv, Shelly, et al.
Publicado: (2018)

hnRNPK recognition of the B motif of Xist and other biological RNAs
por: Nakamoto, Meagan Y, et al.
Publicado: (2020)

Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs
por: Shinoda, Saori, et al.
Publicado: (2019)

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs
por: Van Haute, Lindsey, et al.
Publicado: (2019)

Redefining normal breast cell populations using long noncoding RNAs
por: Bitar, Mainá, et al.
Publicado: (2023)

Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo
por: Kour, Sukhleen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hdgegntcucugt20rujms74eqen