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Relaxed 3D genome conformation facilitates the pluripotent to totipotent-like state transition in embryonic stem cells
The 3D genome organization is crucial for gene regulation. Although recent studies have revealed a uniquely relaxed genome conformation in totipotent early blastomeres of both fertilized and cloned embryos, how weakened higher-order chromatin structure is functionally linked to totipotency acquisiti...
Autores principales: | Zhu, Yezhang, Yu, Jiali, Gu, Jiahui, Xue, Chaoran, Zhang, Long, Chen, Jiekai, Shen, Li |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643704/ https://www.ncbi.nlm.nih.gov/pubmed/34791385 http://dx.doi.org/10.1093/nar/gkab1069 |
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