518. Model-informed Dose Selection of Dual Toll-like Receptor 7/8 Inhibitor Enpatoran (M5049) for the Treatment of COVID-19 Pneumonia

BACKGROUND: Enpatoran, formerly known as M5049, is a potential first-in-class small molecule antagonist of toll-like receptors (TLR) 7 and 8, which may prevent viral-associated hyperinflammatory response and progression to ‘cytokine storm’ in coronavirus disease 2019 (COVID-19) patients. The objecti...

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Detalles Bibliográficos
Autores principales: Klopp-Schulze, Lena, Shaw, Jamie, Dong, Jennifer, Khandelwal, Akash, Adams, Elizabeth, Yu, Dongzi, Goteti, Kosalaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Poster Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643846/
http://dx.doi.org/10.1093/ofid/ofab466.717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643846/
http://dx.doi.org/10.1093/ofid/ofab466.717

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