Cargando…

518. Model-informed Dose Selection of Dual Toll-like Receptor 7/8 Inhibitor Enpatoran (M5049) for the Treatment of COVID-19 Pneumonia

BACKGROUND: Enpatoran, formerly known as M5049, is a potential first-in-class small molecule antagonist of toll-like receptors (TLR) 7 and 8, which may prevent viral-associated hyperinflammatory response and progression to ‘cytokine storm’ in coronavirus disease 2019 (COVID-19) patients. The objecti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klopp-Schulze, Lena, Shaw, Jamie, Dong, Jennifer, Khandelwal, Akash, Adams, Elizabeth, Yu, Dongzi, Goteti, Kosalaram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Poster Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643846/ http://dx.doi.org/10.1093/ofid/ofab466.717

Ejemplares similares

Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8
por: Port, Andreas, et al.
Publicado: (2021)

Applying Modeling and Simulations for Rational Dose Selection of Novel Toll‐Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need
por: Klopp‐Schulze, Lena, et al.
Publicado: (2022)

Comparison of Various Phase I Combination Therapy Designs in Oncology for Evaluation of Early Tumor Shrinkage Using Simulations
por: Seurat, Jérémy, et al.
Publicado: (2020)

Designing phase I oncology dose escalation using dose–exposure–toxicity models as a complementary approach to model‐based dose–toxicity models
por: Pantoja, Kristyn, et al.
Publicado: (2022)

Selection of the Recommended Phase 2 Dose for Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF‐β and PD‐L1
por: Vugmeyster, Yulia, et al.
Publicado: (2020)

518 Prescribing practices of atypical antipsychotics in the burn ICU
por: Gayed, Rita, et al.
Publicado: (2022)

518 myRESEARCHpath: an interactive roadmap for navigating research process, resources, and policies at Duke University
por: Wylie, Jamie, et al.
Publicado: (2022)

PM518. Medication Adherence in schizophrenia: Focus on therapeutic relationship
por: Chang, Jhin-Goo, et al.
Publicado: (2016)

MON-518 Osteoporosis in a Young Adult with Trisomy 13
por: Wynn, Anne, et al.
Publicado: (2019)

THU518 Ectopic Cushing Syndrome In A Case Of Ewing Sarcoma
por: Fasen, Madeline, et al.
Publicado: (2023)

Effect of PF-04634817, an Oral CCR2/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy
por: Gale, Jeremy D., et al.
Publicado: (2018)

To blind or not to blind first in human and exploratory clinical trials: Acceleration of development vs. risk of bias
por: Haertter, Sebastian, et al.
Publicado: (2021)

Epigenetic Mechanisms Are Involved in the Oncogenic Properties of ZNF518B in Colorectal Cancer
por: Gimeno-Valiente, Francisco, et al.
Publicado: (2021)

FRI518 Good For Hair, Skin, And Nails But Bad For Thyroid Lab Tests
por: Khan, Shaza, et al.
Publicado: (2023)

518 Association between Clinical History and Specific IgE Recombinants Latex Allergens
por: Garro, Laila Sabino, et al.
Publicado: (2012)

Involvement of miR-518c-5p to Growth and Metastasis in Oral Cancer
por: Kinouchi, Makoto, et al.
Publicado: (2014)

MicroRNA-518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB
por: Xu, Xiaolong, et al.
Publicado: (2017)

Absolute Measurement of the Refractive Index of Water by a Mode-Locked Laser at 518 nm
por: Meng, Zhaopeng, et al.
Publicado: (2018)

Nanophthalmos patient with a THR518MET mutation in MYRF, a case report
por: Hagedorn, Joshua, et al.
Publicado: (2020)

518. Factors Associated with Severe COVID-19 among Patients Hospitalized in Rhode Island
por: Pandita, Aakriti, et al.
Publicado: (2020)

SAT518 Real World Use of Systemic Therapy for Treatment of Advanced Thyroid Cancer
por: Chen, Debbie, et al.
Publicado: (2023)

Exposure–response analyses for the MET inhibitor tepotinib including patients in the pivotal VISION trial: support for dosage recommendations
por: Xiong, Wenyuan, et al.
Publicado: (2022)

Création de la ligne 8C11: Run 518 - 6 sept. 1974
por: Guignard, G
Publicado: (1974)

A retrospective clinicopathological study on oral lichen planus and malignant transformation: Analysis of 518 cases
por: Shen, Zheng Y., et al.
Publicado: (2012)

51.8 MEDICAL EDUCATION IN THE TIME OF COVID-19: A LITERATURE REVIEW ON E-LEARNING
por: Wu, Alicia S., et al.
Publicado: (2020)

518. Comparing the Mortality of Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae Bacteremia
por: Seo, Hyeonji, et al.
Publicado: (2019)

SAT-518 Progression of Graves Disease to Hashimoto’s Thyroiditis Following Alemtuzumab Therapy for Multiple Sclerosis
por: Rapier, Brandon, et al.
Publicado: (2020)

SUN-518 Graves’ Disease Newly Diagnosed in the Setting of Hypokalemic Periodic Paralysis in an HIV+ Patient
por: Nosova, Emily V, et al.
Publicado: (2020)

Preferences of patients undergoing hemodialysis – results from a questionnaire-based study with 4,518 patients
por: Janssen, Inger Miriam, et al.
Publicado: (2015)

518. Modeling the Potential Impact of Administering Vaccines Against Clostridium difficile Infection to Individuals in Healthcare Facilities
por: Toth, Damon, et al.
Publicado: (2018)

Distribution of Lymphoma Subtypes in Bihar—Analysis of 518 Cases Using the WHO Classification of Lymphoid Tumors (2017)
por: Lisa, Mona, et al.
Publicado: (2020)

518 Autologous Skin Cell Suspensions for Reconstruction of Nonthermal Soft Tissue Wounds: A Case Series
por: Deville, Paige, et al.
Publicado: (2023)

Adición al artículo 518 de la Ley federal del trabajo en materia de prescripción
por: García Fernández, María Julieta
Publicado: (2002)

MCPD 70-518 exam ref: designing and developing Windows applications using Microsoft.NET Framework 4
por: Northrup, Anthony, et al.
Publicado: (2011)

p518, a small floR plasmid from a South American isolate of Actinobacillus pleuropneumoniae
por: da Silva, Giarlã Cunha, et al.
Publicado: (2017)

P518: VENETOCLAX AND AZACITIDINE COMBINED WITH CHIDAMIDE (VAC) FOR THE TREATMENT OF NEWLY DIAGNOSED ACUTE MONOCYTIC LEUKEMIA PATIENTS
por: LI, Zheng, et al.
Publicado: (2023)

Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells
por: Rubie, Claudia, et al.
Publicado: (2014)

Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10)
por: DENG, WEN, et al.
Publicado: (2013)

Micro-RNAs 518d-3p and 618 Are Upregulated in Individuals With Type 1 Diabetes With Multiple Microvascular Complications
por: Santos-Bezerra, Daniele P., et al.
Publicado: (2019)

ZNF518B gene up-regulation promotes dissemination of tumour cells and is governed by epigenetic mechanisms in colorectal cancer
por: Gimeno-Valiente, Francisco, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_v8kp3s7l1deral5fdj49lsv50a