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130. Design and Preclinical Characterization of SER-155, an Investigational Cultivated Microbiome Therapeutic to Restore Colonization Resistance and Prevent Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation

BACKGROUND: During allogeneic hematopoietic stem cell transplant (HSCT), the diversity and stability of the GI microbiome is disrupted, increasing the risk of domination by pathogens associated with bacteremia, aGvHD, and mortality. SER-155 is an investigational, oral microbiome therapeutic composed...

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Detalles Bibliográficos
Autores principales: Halvorsen, Elizabeth, Vulic, Marin, O’Brien, Edward J, Byrant, Jessica, Lombardo, Mary-Jane, Ford, Christopher, Henn, Matt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8644327/
http://dx.doi.org/10.1093/ofid/ofab466.130