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584. Phase 1 Placebo-Controlled Trial of COVI-VAC™, an Intranasal, Live Attenuated COVID-19 Vaccine

BACKGROUND: COVI-VAC(TM) is an intra-nasal live-attenuated SARS-COV-2 synthetic viral vaccine being developed for the prevention of COVID-19. COVI-VAC is attenuated through deletion of the furin cleavage site and introduction of 283 silent deoptimizing mutations that maintain viral amino acid sequen...

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Detalles Bibliográficos
Autores principales: Tasker, Sybil, Bendel, Daryl, Bevan, Melissa, Mueller, Steffen, Kushnir, Anna, Londt, Brandon, Robert Coleman, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8644858/
http://dx.doi.org/10.1093/ofid/ofab466.782