Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma

Knowledge of 1p/19q-codeletion and IDH1/2 mutational status is necessary to interpret any investigational study of diffuse gliomas in the modern era. While DNA sequencing is the gold standard for determining IDH mutational status, genome-wide methylation arrays and gene expression profiling have bee...

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Detalles Bibliográficos
Autores principales: Nuechterlein, Nicholas, Shapiro, Linda G., Holland, Eric C., Cimino, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645099/
https://www.ncbi.nlm.nih.gov/pubmed/34863298
http://dx.doi.org/10.1186/s40478-021-01295-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645099/
https://www.ncbi.nlm.nih.gov/pubmed/34863298
http://dx.doi.org/10.1186/s40478-021-01295-3

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