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Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma

Knowledge of 1p/19q-codeletion and IDH1/2 mutational status is necessary to interpret any investigational study of diffuse gliomas in the modern era. While DNA sequencing is the gold standard for determining IDH mutational status, genome-wide methylation arrays and gene expression profiling have bee...

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Detalles Bibliográficos
Autores principales:	Nuechterlein, Nicholas, Shapiro, Linda G., Holland, Eric C., Cimino, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645099/ https://www.ncbi.nlm.nih.gov/pubmed/34863298 http://dx.doi.org/10.1186/s40478-021-01295-3

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