Cargando…

Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Carcinoma by Inhibiting IL-6 Signaling Pathway

PURPOSE: To characterize the mechanism by which metformin inhibits PD-L1 expression in esophageal squamous cell carcinoma (ESCC) and to evaluate the effect of metformin on the antitumor immune response. METHODS: The Cancer Genome Atlas (TCGA) database was used to analyze the correlations between IL-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Yao, Xin, Dao, Guan, Lulu, Xu, Mengli, Yang, Yalan, Chen, Yu, Yang, Yuanyuan, Wang-Gillam, Andrea, Wang, Li, Zong, Shanggang, Wang, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645640/ https://www.ncbi.nlm.nih.gov/pubmed/34881181 http://dx.doi.org/10.3389/fonc.2021.762523

Ejemplares similares

Erratum: Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Carcinoma by Inhibiting IL-6 Signaling Pathway
Publicado: (2021)

PD-1 Inhibitor Plus Chemotherapy Versus Chemotherapy as First-line Treatment for Advanced Esophageal Cancer: A Systematic Review and Meta-Analysis
por: Lu, Yao, et al.
Publicado: (2022)

Research trends on anti-PD-1/PD-L1 immunotherapy for esophageal cancer: A bibliometric analysis
por: Yang, Yuanyuan, et al.
Publicado: (2022)

The efficacy and safety of antibodies targeting PD-1 for treatment in advanced esophageal cancer: A systematic review and meta-analysis
por: Lu, Yao, et al.
Publicado: (2021)

Reactivation of mutant p53 in esophageal squamous cell carcinoma by isothiocyanate inhibits tumor growth
por: Guan, Lulu, et al.
Publicado: (2023)

A Novel Predictor of Pathologic Complete Response for Neoadjuvant Immunochemotherapy in Resectable Locally Advanced Esophageal Squamous Cell Carcinoma
por: Yang, Yalan, et al.
Publicado: (2023)

PMS2 Expression With Combination of PD-L1 and TILs for Predicting Survival of Esophageal Squamous Cell Carcinoma
por: Jiang, Dongxian, et al.
Publicado: (2022)

Efficacy and safety of anti-PD-1 antibody plus chemoradiotherapy in locally advanced esophageal squamous cancer
por: Ma, Ji, et al.
Publicado: (2023)

Estrogen Receptor Downregulates Expression of PD-1/PD-L1 and Infiltration of CD8(+) T Cells by Inhibiting IL-17 Signaling Transduction in Breast Cancer
por: Shuai, Chong, et al.
Publicado: (2020)

The Combination Options and Predictive Biomarkers of PD-1/PD-L1 Inhibitors in Esophageal Cancer
por: Yang, Hui, et al.
Publicado: (2020)

Metformin inhibits the migration and invasion of esophageal squamous cell carcinoma cells by downregulating the protein kinase B signaling pathway
por: He, Yindi, et al.
Publicado: (2018)

Distribution of residual tumors in esophageal squamous cell carcinoma after neoadjuvant PD-1 blockade combined with chemotherapy
por: Jiang, Dongxian, et al.
Publicado: (2023)

IL6 and BCL3 Expression Are Potential Biomarkers in Esophageal Squamous Cell Carcinoma
por: Soares-Lima, Sheila Coelho, et al.
Publicado: (2021)

Increases prognostic value of clinical-pathological nomogram in patients with esophageal squamous cell carcinoma
por: Hu, Jing Feng, et al.
Publicado: (2023)

Comparison of PD-1 Inhibitors in Patients With Advanced Esophageal Squamous Cell Carcinoma in the Second-Line Setting
por: Zhou, Yi-Xin, et al.
Publicado: (2021)

Combined Metabolomic Analysis of Plasma and Tissue Reveals a Prognostic Risk Score System and Metabolic Dysregulation in Esophageal Squamous Cell Carcinoma
por: Chen, Zhongjian, et al.
Publicado: (2020)

Serum Metabolomic Profiling Reveals Biomarkers for Early Detection and Prognosis of Esophageal Squamous Cell Carcinoma
por: Wang, Pan Pan, et al.
Publicado: (2022)

Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
por: Feng, Y, et al.
Publicado: (2014)

Pretreatment plasma fibrinogen and serum albumin levels predict therapeutic efficacy of concurrent radiochemotherapy for esophageal squamous cell cancer
por: Wang, Jijin, et al.
Publicado: (2022)

The Role of Tumor Microenvironment in Invasion and Metastasis of Esophageal Squamous Cell Carcinoma
por: Zheng, Shuyue, et al.
Publicado: (2022)

Suppression of Esophageal Squamous Cell Carcinoma Development by Mechanosensitive Protein Piezo1 Downregulation
por: Gao, Lu, et al.
Publicado: (2021)

Relationship Between PTEN and Angiogenesis of Esophageal Squamous Cell Carcinoma and the Underlying Mechanism
por: Yang, Chenbo, et al.
Publicado: (2021)

Overcoming resistance to PD-1/PD-L1 inhibitors in esophageal cancer
por: Cheng, Chao, et al.
Publicado: (2022)

Genomic Variations in Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma
por: Yasar, Hatime A
Publicado: (2023)

Case Report: Management of Recurrent Ovarian Squamous Cell Carcinoma With PD-1 Inhibitor
por: Song, Xiao-chen, et al.
Publicado: (2022)

CDKL3 Targets ATG5 to Promote Carcinogenesis of Esophageal Squamous Cell Carcinoma
por: Zhou, Suna, et al.
Publicado: (2020)

Computed Tomography-Based Radiomics in Predicting T Stage and Length of Esophageal Squamous Cell Carcinoma
por: Yang, Mingwei, et al.
Publicado: (2021)

Upregulation of IBSP Expression Predicts Poor Prognosis in Patients With Esophageal Squamous Cell Carcinoma
por: Wang, Mingyue, et al.
Publicado: (2019)

Contrast-Enhanced CT-Based Radiomics Analysis in Predicting Lymphovascular Invasion in Esophageal Squamous Cell Carcinoma
por: Li, Yang, et al.
Publicado: (2021)

Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma
por: Guo, Wenzheng, et al.
Publicado: (2020)

Clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma
por: Wei, Meng Xia, et al.
Publicado: (2023)

Correction to “Suppression of Esophageal Squamous Cell Carcinoma Development by Mechanosensitive Protein Piezo1 Downregulation”
por: Gao, Lu, et al.
Publicado: (2021)

Corrigendum: CDKL3 Targets ATG5 to Promote Carcinogenesis of Esophageal Squamous Cell Carcinoma
por: Zhou, Suna, et al.
Publicado: (2021)

The prognostic value of tumor length to resectable esophageal squamous cell carcinoma: a retrospective study
por: Zhang, Xiangwei, et al.
Publicado: (2017)

DNA Polymerase Iota Promotes Esophageal Squamous Cell Carcinoma Proliferation Through Erk-OGT-Induced G6PD Overactivation
por: Su, Zhenzi, et al.
Publicado: (2021)

Editorial: Genetics and Molecular Mechanisms of Oral and Esophageal Squamous Cell Carcinoma
por: Qiao, Bin, et al.
Publicado: (2022)

Corrigendum: Contrast-Enhanced CT-Based Radiomics Analysis in Predicting Lymphovascular Invasion in Esophageal Squamous Cell Carcinoma
por: Li, Yang, et al.
Publicado: (2021)

Transgelin Inhibits the Malignant Progression of Esophageal Squamous Cell Carcinomas by Regulating Epithelial–Mesenchymal Transition
por: Yang, Boli, et al.
Publicado: (2021)

IL-33 Participates in the Development of Esophageal Adenocarcinoma
por: Liu, Jia, et al.
Publicado: (2022)

Long-term effect of hospital volume on the postoperative prognosis of 158,618 patients with esophageal squamous cell carcinoma in China
por: Lei, Ling-Ling, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_v43logu1cr8u6aaip246o4d9jq