ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis

BACKGROUND & AIMS: Fibrosis, the primary cause of morbidity in chronic liver disease, is induced by pro-inflammatory cytokines, immune cell infiltrates, and tissue resident cells that drive excessive myofibroblast activation, collagen production, and tissue scarring. Rho-associated kinase 2 (ROC...

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Detalles Bibliográficos
Autores principales: Nalkurthi, Christina, Schroder, Wayne A., Melino, Michelle, Irvine, Katharine M., Nyuydzefe, Melanie, Chen, Wei, Liu, Jing, Teng, Michele W.L., Hill, Geoffrey R., Bertolino, Patrick, Blazar, Bruce R., Miller, Gregory C., Clouston, Andrew D., Zanin-Zhorov, Alexandra, MacDonald, Kelli P.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645924/
https://www.ncbi.nlm.nih.gov/pubmed/34917911
http://dx.doi.org/10.1016/j.jhepr.2021.100386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645924/
https://www.ncbi.nlm.nih.gov/pubmed/34917911
http://dx.doi.org/10.1016/j.jhepr.2021.100386

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