Two redundant ubiquitin‐dependent pathways of BRCA1 localization to DNA damage sites

The tumor suppressor BRCA1 accumulates at sites of DNA damage in a ubiquitin‐dependent manner. In this work, we revisit the role of RAP80 in promoting BRCA1 recruitment to damaged chromatin. We find that RAP80 acts redundantly with the BRCA1 RING domain to promote BRCA1 recruitment to DNA damage sit...

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Detalles Bibliográficos
Autores principales: Sherker, Alana, Chaudhary, Natasha, Adam, Salomé, Heijink, Anne Margriet, Noordermeer, Sylvie M, Fradet‐Turcotte, Amélie, Durocher, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647010/
https://www.ncbi.nlm.nih.gov/pubmed/34726323
http://dx.doi.org/10.15252/embr.202153679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647010/
https://www.ncbi.nlm.nih.gov/pubmed/34726323
http://dx.doi.org/10.15252/embr.202153679

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