Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation

Variants of the oncogenic EML4‐ALK fusion protein contain a similar region of ALK encompassing the kinase domain, but different portions of EML4. Here, we show that EML4‐ALK V1 and V3 proteins form cytoplasmic foci that contain components of the MAPK, PLCγ and PI3K signalling pathways. The ALK inhib...

Descripción completa

Detalles Bibliográficos
Autores principales: Sampson, Josephina, Richards, Mark W, Choi, Jene, Fry, Andrew M, Bayliss, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647013/
https://www.ncbi.nlm.nih.gov/pubmed/34661367
http://dx.doi.org/10.15252/embr.202153693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647013/
https://www.ncbi.nlm.nih.gov/pubmed/34661367
http://dx.doi.org/10.15252/embr.202153693

Ejemplares similares