Promyelocytic leukemia protein targets MK2 to promote cytotoxicity

Promyelocytic leukemia protein (PML) is a tumor suppressor possessing multiple modes of action, including induction of apoptosis. We unexpectedly find that PML promotes necroptosis in addition to apoptosis, with Pml (−/−) macrophages being more resistant to TNF‐mediated necroptosis than wild‐type co...

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Detalles Bibliográficos
Autores principales: Chen, I‐Ting, Chen, Hsiao‐Chi, Lo, Yu‐Hsun, Lai, Peng‐Yeh, Hsieh, Fu‐Yi, Wu, Yung‐Hsuan, Shih, Hsiu‐Ming, Lai, Ming‐Zong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647022/
https://www.ncbi.nlm.nih.gov/pubmed/34633746
http://dx.doi.org/10.15252/embr.202052254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647022/
https://www.ncbi.nlm.nih.gov/pubmed/34633746
http://dx.doi.org/10.15252/embr.202052254

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