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Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
Promyelocytic leukemia protein (PML) is a tumor suppressor possessing multiple modes of action, including induction of apoptosis. We unexpectedly find that PML promotes necroptosis in addition to apoptosis, with Pml (−/−) macrophages being more resistant to TNF‐mediated necroptosis than wild‐type co...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647022/ https://www.ncbi.nlm.nih.gov/pubmed/34633746 http://dx.doi.org/10.15252/embr.202052254 |