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PLK1‐dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV‐infected mice

While Epstein–Barr virus (EBV) establishes a life‐long latent infection in apparently healthy human immunocompetent hosts, immunodeficient individuals are at particular risk to develop lymphoproliferative B‐cell malignancies caused by EBV. A key EBV protein is the transcription factor EBV nuclear an...

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Detalles Bibliográficos
Autores principales: Zhang, Xiang, Schuhmachers, Patrick, Mourão, André, Giansanti, Piero, Murer, Anita, Thumann, Sybille, Kuklik‐Roos, Cornelia, Beer, Sophie, Hauck, Stefanie M, Hammerschmidt, Wolfgang, Küppers, Ralf, Kuster, Bernhard, Raab, Monika, Strebhardt, Klaus, Sattler, Michael, Münz, Christian, Kempkes, Bettina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647151/
https://www.ncbi.nlm.nih.gov/pubmed/34605140
http://dx.doi.org/10.15252/embr.202153007