Roles of the hydroxy group of tyrosine in crystal structures of Sulfurisphaera tokodaii O (6)-methylguanine-DNA methyltransferase

O (6)-Methylguanine-DNA methyltransferase (MGMT) removes cytotoxic O (6)-alkyl adducts on the guanine base and protects the cell from genomic damage induced by alkylating agents. Although there are reports of computational studies on the activity of the enzyme with mutations at tyrosine residues, no...

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Detalles Bibliográficos
Autores principales: Kikuchi, Makiko, Yamauchi, Takahiro, Iizuka, Yasuhito, Tsunoda, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647212/
https://www.ncbi.nlm.nih.gov/pubmed/34866599
http://dx.doi.org/10.1107/S2053230X21011055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647212/
https://www.ncbi.nlm.nih.gov/pubmed/34866599
http://dx.doi.org/10.1107/S2053230X21011055

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