Selective targeting of angiopoietin-like 3 (ANGPTL3) with vupanorsen for the treatment of patients with familial partial lipodystrophy (FPLD): results of a proof-of-concept study

BACKGROUND: Familial partial lipodystrophy (FPLD) is a rare disease characterized by selective loss of peripheral subcutaneous fat, associated with dyslipidemia and diabetes mellitus. Reductions in circulating levels of ANGPTL3 are associated with lower triglyceride and other atherogenic lipids, mak...

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Detalles Bibliográficos
Autores principales: Foss-Freitas, Maria C., Akinci, Baris, Neidert, Adam, Bartlett, Victoria J., Hurh, Eunju, Karwatowska-Prokopczuk, Ewa, Oral, Elif A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647384/
https://www.ncbi.nlm.nih.gov/pubmed/34865644
http://dx.doi.org/10.1186/s12944-021-01589-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647384/
https://www.ncbi.nlm.nih.gov/pubmed/34865644
http://dx.doi.org/10.1186/s12944-021-01589-4

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