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Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d(+) Antibody-Mediated Rejection in Kidney Transplant Recipients

BACKGROUND: Solid-phase assays to investigate the complement-activating capacity of HLA antibodies have been utilized to optimize organ allocation and improve transplant outcomes. The clinical utility of C1q/C3d-binding characteristics of de novo donor-specific anti-HLA antibodies (dnDSA) associated...

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Detalles Bibliográficos
Autores principales: Tatapudi, Vasishta S., Kopchaliiska, Dessislava, da Gente, Gilberto J., Buenaventura, Owen F., Singh, Manpreet, Laszik, Zoltan, Adey, Deborah B., Rajalingam, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647455/
https://www.ncbi.nlm.nih.gov/pubmed/34848674
http://dx.doi.org/10.12659/AOT.934175