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Immunization with short peptide particles reveals a functional CD8(+) T-cell neoepitope in a murine renal carcinoma model
BACKGROUND: Induction of CD8(+) T cells that recognize immunogenic, mutated protein fragments in the context of major histocompatibility class I (MHC-I) is a pressing challenge for cancer vaccine development. METHODS: Using the commonly used murine renal adenocarcinoma RENCA cancer model, MHC-I rest...
Autores principales: | He, Xuedan, Zhou, Shiqi, Dolan, Melissa, Shi, Yuhao, Wang, Jianxin, Quinn, Breandan, Jahagirdar, Dushyant, Huang, Wei-Chiao, Tsuji, Moriya, Pili, Roberto, Ito, Fumito, Ortega, Joaquin, Abrams, Scott I, Ebos, John M L, Lovell, Jonathan F |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647534/ https://www.ncbi.nlm.nih.gov/pubmed/34862254 http://dx.doi.org/10.1136/jitc-2021-003101 |
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