Genital Mucosal Drug Concentrations and anti-HIV Activity in Tenofovir-Based PrEP Products: Intravaginal Ring vs. Oral Administration

To describe and compare systemic and local pharmacokinetics (PK) and cervicovaginal (CV) pharmacodynamics (PD) of oral tenofovir disoproxil fumarate (TDF) in combination with emtricitabine (FTC) with tenofovir (TFV) intravaginal ring (IVR). DESIGN: Phase I, randomized, parallel-group study. Women (n...

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Detalles Bibliográficos
Autores principales: Ouattara, Louise A., Thurman, Andrea R., Jacot, Terry A., Cottrell, Mackenzie, Sykes, Craig, Blake, Kimberly, Fang, Xi, Ju, Susan, Vann, Nikolas C., Schwartz, Jill, Doncel, Gustavo F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAIDS Journal of Acquired Immune Deficiency Syndromes 2022
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647693/
https://www.ncbi.nlm.nih.gov/pubmed/34878438
http://dx.doi.org/10.1097/QAI.0000000000002820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647693/
https://www.ncbi.nlm.nih.gov/pubmed/34878438
http://dx.doi.org/10.1097/QAI.0000000000002820

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