Delayed DNA replication in haploid human embryonic stem cells

Haploid human embryonic stem cells (ESCs) provide a powerful genetic system but diploidize at high rates. We hypothesized that diploidization results from aberrant DNA replication. To test this, we profiled DNA replication timing in isogenic haploid and diploid ESCs. The greatest difference was the...

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Detalles Bibliográficos
Autores principales: Edwards, Matthew M., Zuccaro, Michael V., Sagi, Ido, Ding, Qiliang, Vershkov, Dan, Benvenisty, Nissim, Egli, Dieter, Koren, Amnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647822/
https://www.ncbi.nlm.nih.gov/pubmed/34810218
http://dx.doi.org/10.1101/gr.275953.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647822/
https://www.ncbi.nlm.nih.gov/pubmed/34810218
http://dx.doi.org/10.1101/gr.275953.121

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