Cargando…

Decoding the function of bivalent chromatin in development and cancer

Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and H3K27me3, histone modifications generally associated with transcriptionally active and repressed chromatin, respectively. Prevalent in embryonic stem cells (ESCs), bivalency is postulated to poise/prime lineage-controlli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Dhirendra, Cinghu, Senthilkumar, Oldfield, Andrew J., Yang, Pengyi, Jothi, Raja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647824/ https://www.ncbi.nlm.nih.gov/pubmed/34667120 http://dx.doi.org/10.1101/gr.275736.121

Ejemplares similares

NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region
por: Oldfield, Andrew J., et al.
Publicado: (2019)

Transcriptional network dynamics during the progression of pluripotency revealed by integrative statistical learning
por: Kim, Hani Jieun, et al.
Publicado: (2020)

Generation of bivalent chromatin domains during cell fate decisions
por: De Gobbi, Marco, et al.
Publicado: (2011)

Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer
por: Bernhart, Stephan H., et al.
Publicado: (2016)

Decoding the epigenetic effects of chromatin
por: Festenstein, Richard, et al.
Publicado: (2003)

Mathematical modeling of histone modifications reveals the formation mechanism and function of bivalent chromatin
por: Zhao, Wei, et al.
Publicado: (2021)

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis
por: Pathania, Rajneesh, et al.
Publicado: (2015)

Bivalent chromatin as a therapeutic target in cancer: An in silico predictive approach for combining epigenetic drugs
por: Alarcón, Tomás, et al.
Publicado: (2021)

Transcriptional Regulation of Structural and Functional Adaptations in a Developing Adulthood Myocardium
por: Sunny, Sini, et al.
Publicado: (2021)

Bivalent-Like Chromatin Markers Are Predictive for Transcription Start Site Distribution in Human
por: Zhang, Zhihua, et al.
Publicado: (2012)

Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline
por: Sin, Ho-Su, et al.
Publicado: (2015)

Decoding the role of chromatin architecture in development: coming closer to the end of the tunnel
por: Luo, Chongyuan, et al.
Publicado: (2014)

Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin
por: Schrott, Rose, et al.
Publicado: (2020)

Age-Associated Hyper-Methylated Regions in the Human Brain Overlap with Bivalent Chromatin Domains
por: Watson, Corey T., et al.
Publicado: (2012)

The Role of Multiple Marks in Epigenetic Silencing and the Emergence of a Stable Bivalent Chromatin State
por: Mukhopadhyay, Swagatam, et al.
Publicado: (2013)

Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
por: Sneppen, Kim, et al.
Publicado: (2019)

Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data
por: Yang, Pengyi, et al.
Publicado: (2015)

An annotated list of bivalent chromatin regions in human ES cells: a new tool for cancer epigenetic research
por: Court, Franck, et al.
Publicado: (2016)

Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation
por: Klein, Brianna J., et al.
Publicado: (2016)

An orienting response is not enough: Bivalency not infrequency causes the bivalency effect
por: Rey-Mermet, Alodie, et al.
Publicado: (2013)

Imprinting control regions (ICRs) are marked by mono-allelic bivalent chromatin when transcriptionally inactive
por: Maupetit-Méhouas, Stéphanie, et al.
Publicado: (2016)

Integrative Proteome Analysis Revels 3-Hydroxybutyrate Exerts Neuroprotective Effect by Influencing Chromatin Bivalency
por: Zhu, Xin-Liang, et al.
Publicado: (2023)

Kaposi’s sarcoma-associated herpesvirus promotes mesenchymal-to-endothelial transition by resolving the bivalent chromatin of PROX1 gene
por: Ding, Yao, et al.
Publicado: (2021)

Decoding the chromatin proteome of a single genomic locus by DNA sequencing
por: Korthout, Tessy, et al.
Publicado: (2018)

Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis
por: Chen, Jiahuan, et al.
Publicado: (2020)

A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
por: Sendžikaitė, Gintarė, et al.
Publicado: (2019)

Cocaine regulation of Nr4a1 chromatin bivalency and mRNA in male and female mice
por: Fischer, Delaney K., et al.
Publicado: (2022)

Bivalent histone modifications during tooth development
por: Zheng, Li-Wei, et al.
Publicado: (2014)

A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development
por: Schertel, Claus, et al.
Publicado: (2015)

Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
por: Terranova, Christopher J., et al.
Publicado: (2021)

Histone bivalency regulates the timing of cerebellar granule cell development
por: Mätlik, Kärt, et al.
Publicado: (2023)

An essential domain of an early-diverged RNA polymerase II functions to accurately decode a primitive chromatin landscape
por: Das, Anish, et al.
Publicado: (2017)

A novel bivalent chromatin associates with rapid induction of camalexin biosynthesis genes in response to a pathogen signal in Arabidopsis
por: Zhao, Kangmei, et al.
Publicado: (2021)

The Arabidopsis homologs of trithorax (ATX1) and enhancer of zeste (CLF) establish ‘bivalent chromatin marks’ at the silent AGAMOUS locus
por: Saleh, Abdelaty, et al.
Publicado: (2007)

The Arabidopsis homologs of trithorax (ATX1) and enhancer of zeste (CLF) establish ‘bivalent chromatin marks’ at the silent AGAMOUS locus
por: Saleh, Abdelaty, et al.
Publicado: (2016)

Integrative analysis reveals histone demethylase LSD1 promotes RNA polymerase II pausing
por: Kim, Hani Jieun, et al.
Publicado: (2022)

Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state
por: Carraro, Caterina, et al.
Publicado: (2022)

Decoding the heterogeneous landscape in the development prostate cancer
por: Segura-Moreno, Yenifer Yamile, et al.
Publicado: (2021)

Histone bivalency regulates the timing of cerebellar granule cell development
por: Mätlik, Kärt, et al.
Publicado: (2023)

Development of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs
por: Kou, Ponien, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qtreksmtetqgddhbdi5ijqbl3t