Global quantification exposes abundant low-level off-target activity by base editors

Base editors are dedicated engineered deaminases that enable directed conversion of specific bases in the genome or transcriptome in a precise and efficient manner, and hold promise for correcting pathogenic mutations. A major concern limiting application of this powerful approach is the issue of of...

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Detalles Bibliográficos
Autores principales: Buchumenski, Ilana, Roth, Shalom Hillel, Kopel, Eli, Katsman, Efrat, Feiglin, Ariel, Levanon, Erez Y., Eisenberg, Eli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647836/
https://www.ncbi.nlm.nih.gov/pubmed/34667118
http://dx.doi.org/10.1101/gr.275770.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647836/
https://www.ncbi.nlm.nih.gov/pubmed/34667118
http://dx.doi.org/10.1101/gr.275770.121

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