An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity

In breast cancer, genetic heterogeneity, the lack of actionable targets, and immune evasion all contribute to the limited clinical response rates to immune checkpoint blockade therapy. Here, we report a high-throughput screen based on the functional interaction of mouse or patient-derived breast tum...

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Detalles Bibliográficos
Autores principales: Zhou, Zhuolong, Van der Jeught, Kevin, Fang, Yuanzhang, Yu, Tao, Li, Yujing, Ao, Zheng, Liu, Sheng, Zhang, Lu, Yang, Yang, Eyvani, Haniyeh, Cox, Mary L., Wang, Xiyu, He, Xiaoming, Ji, Guang, Schneider, Bryan P., Guo, Feng, Wan, Jun, Zhang, Xinna, Lu, Xiongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647932/
https://www.ncbi.nlm.nih.gov/pubmed/34725507
http://dx.doi.org/10.1038/s41551-021-00805-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647932/
https://www.ncbi.nlm.nih.gov/pubmed/34725507
http://dx.doi.org/10.1038/s41551-021-00805-x

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