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Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles

CONTEXT: As an inhibitor cytochrome P450 family 2 subfamily C polypeptide 8 (CYP2C8), quercetin is a naturally occurring flavonoid with its glycosides consumed at least 100 mg per day in food. However, it is still unknown whether quercetin and selexipag interact. OBJECTIVE: The study investigated th...

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Detalles Bibliográficos
Autores principales:	Luo, Shun-bin, Gu, Er-min, Chen, Yu-ao, Zhou, Shi-chen, Fan, Chen, Xu, Ren-ai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648015/ https://www.ncbi.nlm.nih.gov/pubmed/34860644 http://dx.doi.org/10.1080/13880209.2021.2005636

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