Methylglyoxal Exacerbates Lipopolysaccharide-Induced Acute Lung Injury via RAGE-Induced ROS Generation: Protective Effects of Metformin

PURPOSE: Methylglyoxal (MGO) is a highly reactive dicarbonyl species implicated in diabetic-associated diseases. Acute lung injury (ALI) symptoms and prognosis are worsened by diabetes and obesity. Here, we hypothesized that elevated MGO levels aggravate ALI, which can be prevented by metformin. The...

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Detalles Bibliográficos
Autores principales: Medeiros, Matheus L, Oliveira, Akila L, de Oliveira, Mariana G, Mónica, Fabíola Z, Antunes, Edson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648108/
https://www.ncbi.nlm.nih.gov/pubmed/34880648
http://dx.doi.org/10.2147/JIR.S337115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648108/
https://www.ncbi.nlm.nih.gov/pubmed/34880648
http://dx.doi.org/10.2147/JIR.S337115

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