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De novo protein fold families expand the designable ligand binding site space
A major challenge in designing proteins de novo to bind user-defined ligands with high affinity is finding backbones structures into which a new binding site geometry can be engineered with high precision. Recent advances in methods to generate protein fold families de novo have expanded the space o...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648124/ https://www.ncbi.nlm.nih.gov/pubmed/34807909 http://dx.doi.org/10.1371/journal.pcbi.1009620 |