IM-2 Possibility of immunotherapy for the glioblastoma patients with O6-methyl-guanine DNA methyltransferase (MGMT) expression or promoter unmethylated

Background: MGMT is a DNA repair protein that removes the cytotoxic O6-methylguanine (O6MG) DNA lesions generated by TMZ; thereby, MGMT expression is mechanistically linked to TMZ resistance. However, thus far, there is no effective treatment for these patients with MGMT promoter unmethylated. There...

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Detalles Bibliográficos
Autores principales: Kushihara, Yoshihiro, Tanaka, Shota, Nanbu, Shohei, Kugasawa, Kazuha, Yamasawa, Erika, Takami, Hirokazu, Takayanagi, Shunsaku, Kakimi, Kazuhiro, Saito, Nobuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648188/
http://dx.doi.org/10.1093/noajnl/vdab159.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648188/
http://dx.doi.org/10.1093/noajnl/vdab159.026

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