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NQPC-5 Does high-dose methotrexate-based chemotherapy for relapsed primary CNS lymphoma increase a risk of leukoencephalopathy with prior whole brain radiotherapy?

Backgrounds: Standard care for primary central nervous system lymphoma (PCNSL) comprises high-dose (HD) methotrexate (MTX) -based chemotherapy with or without consolidation whole brain radiotherapy (WBRT). HD-MTX administration following WBRT has been suggested to increase a risk of leukoencephalopa...

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Detalles Bibliográficos
Autores principales: Kobayashi, Keiichi, Sasaki, Nobuyoshi, Saito, Kuniaki, Yamagishi, Yuki, Hanayama, Naomi, Nakatomi, Hirofumi, Shiokawa, Yoshiaki, Nagane, Motoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648221/
http://dx.doi.org/10.1093/noajnl/vdab159.083