Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb

The positive transcription elongation factor b (P-TEFb) is a critical coactivator for transcription of most cellular and viral genes, including those of HIV. While P-TEFb is regulated by 7SK snRNA in proliferating cells, P-TEFb is absent due to diminished levels of CycT1 in quiescent and terminally...

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Detalles Bibliográficos
Autores principales: Huang, Fang, Nguyen, Trang TT, Echeverria, Ignacia, Rakesh, Ramachandran, Cary, Daniele C, Paculova, Hana, Sali, Andrej, Weiss, Arthur, Peterlin, Boris Matija, Fujinaga, Koh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648303/
https://www.ncbi.nlm.nih.gov/pubmed/34821217
http://dx.doi.org/10.7554/eLife.68473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648303/
https://www.ncbi.nlm.nih.gov/pubmed/34821217
http://dx.doi.org/10.7554/eLife.68473

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