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Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires
The antibody (Ab) germline gene rearrangement of variable (V), diversity (D), and joining (J) gene segments, as well as somatic hypermutation, give rise to the human Ab variable gene sequence repertoire. It is common to characterize single nucleotide frequencies of the variable region by alignment t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648325/ https://www.ncbi.nlm.nih.gov/pubmed/32397786 http://dx.doi.org/10.1080/19420862.2020.1758291 |