Cargando…

Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells

Lipidoid nanoparticles (LNPs) are the delivery platform in Onpattro, the first FDA-approved siRNA drug. LNPs are also the carriers in the Pfizer-BioNTech and Moderna COVID-19 mRNA vaccines. While these applications have demonstrated that LNPs effectively deliver nucleic acids to hepatic and muscle c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khare, Purva, Dave, Kandarp M., Kamte, Yashika S., Manoharan, Muthiah A., O’Donnell, Lauren A., Manickam, Devika S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648339/ https://www.ncbi.nlm.nih.gov/pubmed/34873640 http://dx.doi.org/10.1208/s12248-021-00653-2

Ejemplares similares

Lipidoid Nanoparticles for siRNA Delivery to the Intestinal Epithelium: In Vitro Investigations in a Caco-2 Model
por: Ball, Rebecca L., et al.
Publicado: (2015)

Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles
por: Lokras, Abhijeet, et al.
Publicado: (2021)

Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection
por: Ma, Feihe, et al.
Publicado: (2020)

Neural Stem Cells: What Happens When They Go Viral?
por: Kamte, Yashika S., et al.
Publicado: (2021)

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design
por: de Groot, Anne Marit, et al.
Publicado: (2018)

In situ cancer vaccination using lipidoid nanoparticles
por: Chen, Jinjin, et al.
Publicado: (2021)

Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression
por: Place, Robert F, et al.
Publicado: (2012)

Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain
por: Rungta, Ravi L, et al.
Publicado: (2013)

Centyrin ligands for extrahepatic delivery of siRNA
por: Klein, Donna, et al.
Publicado: (2021)

Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity
por: Dolina, Joseph S, et al.
Publicado: (2013)

Molecularly Self-Assembled Nucleic Acid Nanoparticles for Targeted In Vivo siRNA Delivery
por: Lee, Hyukjin, et al.
Publicado: (2012)

Study the lipidoid nanoparticle mediated genome editing protein delivery using 3D intestinal tissue model
por: Yang, Tao, et al.
Publicado: (2021)

Advances in Lipid Nanoparticles for siRNA Delivery
por: Tam, Yuen Yi C., et al.
Publicado: (2013)

BSA Nanoparticles for siRNA Delivery: Coating Effects on Nanoparticle Properties, Plasma Protein Adsorption, and In Vitro siRNA Delivery
por: Yogasundaram, Haran, et al.
Publicado: (2012)

Characterization of the SIM-A9 cell line as a model of activated microglia in the context of neuropathic pain
por: Dave, Kandarp M., et al.
Publicado: (2020)

Identification of siRNA delivery enhancers by a chemical library screen
por: Gilleron, Jerome, et al.
Publicado: (2015)

Intracellular Delivery of siRNA by Polycationic Superparamagnetic Nanoparticles
por: Castillo, Betzaida, et al.
Publicado: (2012)

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
por: Foster, Donald J., et al.
Publicado: (2018)

Albumin pre-coating enhances intracellular siRNA delivery of multifunctional amphiphile/siRNA nanoparticles
por: Kummitha, China M, et al.
Publicado: (2012)

Acyclic (S)-glycol nucleic acid (S-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency
por: Egli, Martin, et al.
Publicado: (2023)

Structure–Activity Relationships of Cationic Lipidoids against Escherichia coli
por: Jennings, James, et al.
Publicado: (2023)

Calcium phosphate nanoparticles-based systems for siRNA delivery
por: Xu, Xiaochun, et al.
Publicado: (2016)

Hydrocarbon-Stapled Peptide Based-Nanoparticles for siRNA Delivery
por: Simon, Matthieu, et al.
Publicado: (2020)

Targeted Delivery of siRNA
por: Oliveira, Sabrina, et al.
Publicado: (2006)

Dendrimers for siRNA Delivery
por: Biswas, Swati, et al.
Publicado: (2013)

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**
por: Jayaraman, Muthusamy, et al.
Publicado: (2012)

Enzyme-triggered PEGylated siRNA-nanoparticles for controlled release of siRNA
por: Yingyuad, Peerada, et al.
Publicado: (2014)

Degradable Lipid Nanoparticles with Predictable In Vivo siRNA Delivery Activity
por: Whitehead, Kathryn A., et al.
Publicado: (2014)

Polymeric nanoparticles for the delivery of siRNA and the partnership between WSU and UNIT
por: da Rocha, Sandro, et al.
Publicado: (2014)

Recent Developments in Nanoparticle-Based siRNA Delivery for Cancer Therapy
por: Lee, Jong-Min, et al.
Publicado: (2013)

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
por: Sahay, Gaurav, et al.
Publicado: (2013)

Oral delivery of siRNA lipid nanoparticles: Fate in the GI tract
por: Ball, Rebecca L., et al.
Publicado: (2018)

Cyclic Peptide-Capped Gold Nanoparticles for Enhanced siRNA Delivery
por: Shirazi, Amir Nasrolahi, et al.
Publicado: (2014)

Synthesis of Polymer-Lipid Nanoparticles by Microfluidic Focusing for siRNA Delivery
por: Li, Yujing, et al.
Publicado: (2016)

Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA
por: Elzeny, Hadeel, et al.
Publicado: (2017)

Recent advances in siRNA delivery mediated by lipid-based nanoparticles
por: Yonezawa, Sei, et al.
Publicado: (2020)

Characterization of modified mesoporous silica nanoparticles as vectors for siRNA delivery
por: Slita, Anna, et al.
Publicado: (2018)

Novel Ellipsoid Chitosan-Phthalate Lecithin Nanoparticles for siRNA Delivery
por: Saeed, Ramzi Mukred, et al.
Publicado: (2021)

Harnessing a Physiologic Mechanism for siRNA Delivery With Mimetic Lipoprotein Particles
por: Nakayama, Tomoko, et al.
Publicado: (2012)

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles
por: Mui, Barbara L, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2j32cta7h4s7sohh8gos71lfoc