Adaptive value of foot-and-mouth disease virus capsid substitutions with opposite effects on particle acid stability

Foot-and-mouth disease virus (FMDV) is a picornavirus that exhibits an extremely acid sensitive capsid. This acid lability is directly related to its mechanism of uncoating triggered by acidification inside cellular endosomes. Using a collection of FMDV mutants we have systematically analyzed the re...

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Detalles Bibliográficos
Autores principales: Caridi, Flavia, Cañas-Arranz, Rodrigo, Vázquez-Calvo, Ángela, de León, Patricia, Calderón, Katherine I., Domingo, Esteban, Sobrino, Francisco, Martín-Acebes, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648728/
https://www.ncbi.nlm.nih.gov/pubmed/34873184
http://dx.doi.org/10.1038/s41598-021-02757-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648728/
https://www.ncbi.nlm.nih.gov/pubmed/34873184
http://dx.doi.org/10.1038/s41598-021-02757-3

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