Toxicity of internalized polyalanine to cells depends on aggregation

In polyalanine (PA) diseases, the disease-causing transcription factors contain an expansion of alanine repeats. While aggregated proteins that are responsible for the pathogenesis of neurodegenerative disorders show cell-to-cell propagation and thereby exert toxic effects on the recipient cells, wh...

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Detalles Bibliográficos
Autores principales: Iizuka, Yutaro, Owada, Ryuji, Kawasaki, Takayasu, Hayashi, Fumio, Sonoyama, Masashi, Nakamura, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648788/
https://www.ncbi.nlm.nih.gov/pubmed/34873226
http://dx.doi.org/10.1038/s41598-021-02889-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648788/
https://www.ncbi.nlm.nih.gov/pubmed/34873226
http://dx.doi.org/10.1038/s41598-021-02889-6

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