Hepatocyte-specific perturbation of NAD(+) biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis–like phenotypes

Nicotinamide phosphoribosyltransferase (NAMPT) converts nicotinamide to NAD(+). As low hepatic NAD(+) levels have been linked to the development of nonalcoholic fatty liver disease, we hypothesized that ablation of hepatic Nampt would affect susceptibility to liver injury in response to diet-induced...

Descripción completa

Detalles Bibliográficos
Autores principales: Dall, Morten, Hassing, Anna S., Niu, Lili, Nielsen, Thomas S., Ingerslev, Lars R., Sulek, Karolina, Trammell, Samuel A.J., Gillum, Matthew P., Barrès, Romain, Larsen, Steen, Poulsen, Steen S., Mann, Matthias, Ørskov, Cathrine, Treebak, Jonas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648833/
https://www.ncbi.nlm.nih.gov/pubmed/34762911
http://dx.doi.org/10.1016/j.jbc.2021.101388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648833/
https://www.ncbi.nlm.nih.gov/pubmed/34762911
http://dx.doi.org/10.1016/j.jbc.2021.101388

Ejemplares similares